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Target Therapy, Chemotherapy

What is Targeted Therapy in Cancer

Nowadays cancer is very common in all people, in old age, adult, adolescents, children etc. it’s spread very rapidly in each generation. To fight with cancer, pharmaceutical industries have been discovered the targeted therapy.

Since the 1950s, there are significant advances have been made in the chemotherapeutic drug management of the cancer disease. Unfortunately, more than 50% of all cancer patients, both do not respond to an initial therapy or experience relapse after an initial response to treatment and ultimately die from the progressive metastatic disease.

Nowadays, the pharmaceutical industries have been successful in discovering many new cytotoxic/chemotherapeutic drugs which can potentially be used for the treatment of cancer, still, this life-threatening disease still causes near 7 million deaths every year worldwide and the number goes on increasing.

In general, cancer chemotherapy is usually accompanied by severe side effects and acquired drug resistance. Therefore, target therapy is known for cancer which is very effective only on the cancer cell and does not act on the normal cells, which is having fewer side effects and less toxicity.

These targeted agents are only effective in tumor types which are dependent upon the tumor antigens, the pathways that are being inhibited.

The first targeted therapy for breast cancer were hormonal therapies. Then, HER2 targeted therapies for the HER2-positive breast cancer. There is some newer medicine includes in this therapy e.g., Palbociclib (Ibrance) and Everolimus (Afinitor), which are targeted therapies for metastatic ER-positive HER2-negative breast cancer.

Targeted therapy is also used in prevention of growth of cancer which has spread to the bone and also maintains bone health

Targeted therapy is a treatment which targets the cancer cells, specific genes, proteins and also tissue environment.  These treatments are newer and focused on disease. It is different from the chemotherapy. This method of treatment is commonly used in combination with traditional chemotherapy. However, targeted therapy drugs often have less severe side effects than the standard chemotherapy drugs.

Target therapy drugs block the growth of cancer cells while preventing damage to healthy cells. Targeted therapy is very costly, which is unaffordable to everybody.